Matthias gromeier biography
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Matthias Gromeier
Dr.
Matthias gromeier biography
Matthias Gromeier is a Professor in the Department of Neurosurgery at Duke University Medical Center,[1][2] who has developed a way to re-engineer a poliovirus to inspire the human immune system to kill cancer cells in a specific set of cancers.
The re-engineered virus, called PVSRIPO, cannot replicate itself in normal cells, but can replicate itself in cancer cells that have an overabundance of the protein marker that the poliovirus targets.[3]
PVSRIPO, which Gromeier engineered himself as a postdoc in the 1990s[4] is thought to induce an anti-tumor immune response against the tumor.
Phase I trials in glioblastoma (GBM, one of the most deadly brain cancers) results have been very promising. The traditional treatment against GBM, surgical resection followed by chemo usually gives rise to only a 12-month survival in patients; some patients treated with PVSRIPO are still alive, symptomless, 3.5 years after treatment.